Creatine is a naturally occurring compound found in muscle cells and is involved in the production of energy for high-intensity activities. While it is produced endogenously in the body, supplementing with creatine has been extensively studied and shown to provide various benefits for both physical and cognitive health.

Physical Performance and Muscle Growth

Numerous studies have demonstrated the efficacy of creatine supplementation in improving physical performance and promoting muscle growth. A meta-analysis published in the Journal of the International Society of Sports Nutrition in 2017 concluded that creatine supplementation can significantly increase lean muscle mass and strength, especially when combined with resistance training.

The mechanism behind creatine’s ergogenic effects lies in its ability to increase the body’s stores of phosphocreatine, a high-energy compound essential for generating ATP (adenosine triphosphate), the primary energy currency for muscle contractions. By increasing phosphocreatine levels, creatine supplementation allows muscles to sustain high-intensity exercise for longer periods, leading to improved performance in activities like weightlifting, sprinting, and high-intensity interval training (HIIT).

Cognitive Function and Neuroprotection

While creatine is most commonly associated with physical performance, emerging research suggests that it may also provide cognitive benefits and neuroprotective effects. A 2022 systematic review and meta-analysis published in the Journal of the International Society of Sports Nutrition found that creatine supplementation can improve cognitive function, particularly in older adults and individuals with cognitive impairments.

The proposed mechanisms behind creatine’s cognitive benefits include its ability to increase brain creatine levels, which can improve energy metabolism and support neuronal function. Additionally, creatine has been shown to have antioxidant and anti-inflammatory properties, which may protect against neurodegeneration and cognitive decline.

Benefits for Older Adults

As we age, our bodies naturally experience a decline in muscle mass and strength, a condition known as sarcopenia. This age-related muscle loss can lead to reduced mobility, increased risk of falls, and a decreased quality of life. Creatine supplementation has been studied as a potential intervention to combat sarcopenia and support healthy aging.

A 2019 systematic review and meta-analysis published in the Journal of Cachexia, Sarcopenia and Muscle found that creatine supplementation can significantly improve muscle strength and lean muscle mass in older adults, particularly when combined with resistance training. Additionally, creatine may help older adults maintain cognitive function and potentially reduce the risk of age-related cognitive decline.

Safety and Dosing

Creatine is generally considered safe for most individuals when consumed at recommended doses. The most common dosing protocol is to consume 5 grams of creatine monohydrate per day, with or without a loading phase (20-25 grams per day for 5-7 days).

It is essential to note that individuals with pre-existing kidney or liver conditions should consult with a healthcare professional before taking creatine supplements, as there is a theoretical risk of exacerbating these conditions, although research on this is conflicting.

Creatine is a well-researched and scientifically-backed supplement that can provide benefits for physical performance, muscle growth, cognitive function, and healthy aging.

As with any supplement, it is important to consult with a healthcare professional, especially for individuals with pre-existing medical conditions, and to follow appropriate dosing guidelines.